I have never heard of two inconclusive results! Whether patients are referred to us or already have a Cleveland Clinic ob/gyn, we work closely with them to offer treatment recommendations and follow-up care to help you receive the best outcome. Well this clinic doesnt ask people to come back. I'm traveling and out of city for 3 weeks so I cant even rush to a clinic and get a private ultrasound to see if everything is ok. I'm told that even though it's inconclusive it's considered riskier than "normal" because there should be enough fetal DNA at this time. Be sure to understand what the test screens for and what the results mean so you make an informed decision. It does have a lower accuracy rate (around 80%) than NIPT but for me was accurate. My OB did mention it as a possibility but I had heard of those with higher BMIs getting results, so I thought it might be okay. . 4% at least is needed for accuracy. The first draw I did at 12 weeks and second draw did at around 13 weeks 6 days. Thats why the screening isnt performed until 10 weeks into the pregnancy. I have read this is an issue for plus size women and the other factor is age. Create an account or log in to participate. endstream endobj 73 0 obj <>stream Your healthcare provider will receive your test results first, then share the results with you. I'm pretty sure its because I'm overweight lolmanyjow dehydration sounds like a good idea although the first day I went I had puked all morning Anyhow am skipping it now and will just wait till my next appointment which is on the 20th and hopefully we will find out the gender. I had inconclusive NIPT results. NIPT testing doesnt diagnose conditions it only suggests a fetus is more likely to have a particular condition. I did my NIPT bloodwork at 9w 4d and am supposed to have my results back this Friday. Would I do something different knowing the fetus has a genetic condition or an increased risk for a genetic condition? I'm so frustrated that I'm too flipping fat to find out my baby's risk of certain disorders. :). Good luck!! Reasons behind an inconclusive prenatal paternity test. I have also had 2 inconclusive results and we are not trying again. I also did NIPT twice and bouth times it came back inconclusive due to low fetal fraction. New comments cannot be posted and votes cannot be cast. We just got our results back and have a perfectly healthy eggo. endstream endobj startxref hbbd``b` $X- H *H2M) u$B@> LW@b!3.|` hYmo6+bDR$EE iZcKZ2,5V~b)%7QGx{8qfs&,9K dbyb:,Xg1cekX3)-l`Gj%SV0H@1#43*a?+V1bM4^%}*&29Li1I=&~~K&a/e2,VaLFEZE]&7_4NO\Vq9z2.U\b1)0[$@'NmY=B(db~O^6jRJfbZ&\fMeY?RPu A]LaR2rt$\.E=_&ShK+05}rYo"&7xJ|10&,*NOop;~\@`zPd40`Qq[BlJMOnsgU*|]yepYE.+yf Now doing the waiting game!! Were having a boy! The DNA is examined for genetic conditions, such as Down syndrome. For example, you may get a positive or high-risk result for trisomy 13 but a negative or low-risk result for Down syndrome. Policy. The accuracy of the test varies by the condition that its checking for. They kinda downplayed it saying it happens a lot, but it still stresses me out a little. There is a 0% chance of survival with this condition so we are looking into terminating in the next few days not my rainbow baby after all.. Amnio specialist also told me that low fetal fraction can be because of placenta. Lol. Luckily the last vile came back (after 25 days) and everything was fine! Understanding what the NIPT test results mean. I was 164 pre pregnancy and 184 now. Your healthcare provider will discuss all your prenatal screening options, including NIPT. Some radiologists like to comment on ALL the scans the technicians provided even the poor quality ones. I wouldnt have survived with out those ladies. NIPT tests dont diagnose conditions. This happened to me as well. I can send you in the right direction. Im now worried something could be wrong with my baby. We strive to provide you with a high quality community experience. I realize I may have been taking about something different. I was super annoyed, but Im taking her word and hoping all is fine. insufficient DNA for the NIPT test) and chances of a trisomy defect. Just got my results back yesterday with a BMI of 47. Mine came back inconcl, I was 12 weeks and then took again at 14 1D, I have also had 2 inconclusive results and we are not trying again. inconclusive results due to low fetal fraction. This test can also provide information about the sex of the fetus. Please whitelist our site to get all the best deals and offers from our partners. I did my NIPT bloodwork at 9w 4d and am supposed to have my results back this Friday. The first test they ran apparently i did not have enough fetal DNA i took another one and the same results, should I be concerned? Press question mark to learn the rest of the keyboard shortcuts, third time mom / due aug 2023 / 30 / she/her. Just wanted to share my experience since Ive gotten both a CVS and an amniocentesis in the last 3 weeks.Backstory: at my 12 week nuchal translucency scan, we had a high measurement of nuchal fluid (3.5mm). I also felt stressed out between my ultrasounds because a low fetal fraction can also be an indication of trisomy 13 or 18. Oh yes I was referring to a blood test but thank you so much for the input. 2005-2023Everyday Health, Inc., a Ziff Davis company. If your baby still has a heartbeat now, maybe that means that the baby doesnt have that. In Latvia we have to do first trimester screening where they mesure NT and check Papp-a & HCgb levels. No markers or bright spots. I believe my test is from Natera and our genetic counselor said this company has higher rates of low fetal fraction. yeah I declined the redraw also and decided to wait. I've had he NIPT test twice now and had it come back for low fetal DNA. Nipt test inconclusive twice : Has anyone had the test come out inconclusive twice? All rights reserved. I didn't even want them to do that. I feel like Im holding myself together for now but that I can brake at any point so very wary of how I will deal with a second loss in a row :(. Yes, mine came back inconclusive as well. You wont get the gender but youll find out if baby is healthy x x, Im am from Latvia (Europe). - May 2020 Babies | Forums | What to Expect Community > Birth Month May 2020 Babies 97K Discussions 192K Members The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. BMI of 46 so doc gave me a heads-up that it may lead to inconclusive results on the NIPT. Inconclusive NIPT twice! We are going to pursue that because of the rarity of not presenting a result initially. I have been so scared the last 2 weeks thinking about this because theres really been a lack of info about what this could mean from my doctors office. Our commitment to quality means that we will only provide a result when there is very clear evidence for, or against, the presence of a specific disorder. Also at 13w3days I had my. NIPT is a screening test, which means that it wont give a yes or no answer about whether or not a fetus has a condition. Can I ask how your Quad screening went? (https://medlineplus.gov/genetics/understanding/testing/nipt/). Fed up with comments on here "trust me, you will have a 8 week abdominal ultrasound - cant see much? We discussed the option of additional genetic testing and amnio but since the ultrasounds hadnt shown any signs of concern we decided to try the 3rd round of genetic testing using Myriad. %PDF-1.6 % Noninvasive prenatal testing helps determine the fetuss chances of being born with certain chromosomal disorders. If you feel a message or content violates these standards and would like to request its removal please submit the following information and our moderating team will respond shortly. 2005-2023Everyday Health, Inc., a Ziff Davis company. I'm so sorry your going through this stressful situation , Got the quad back! We then did the SAFE nipt as it needs roughly 0.5 dna fraction, where as other nipt tests need at least 4.5% and we got a result!! My anatomy scan went well and the doctor has no other concerns at this point. Learn more about our guidelines Unfortunately, my nuchal translucency came back bad and I am going to have to have an amniocentesis because of the failure of the NIPT to give me the information I needed, therefore raising my risk. No idea what that means. Have had an earlier screening test that suggests a potential problem. So after 9 weeks of genetic testing and no results we were finally able to get results and everything has turned out ok and we are having a baby boy! Im so so sorry to hear about your loss. By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. NIPT testing is optional. How far along were you when you took each one? I took the testing at 16 was I. , I agree with PP. thank you - apparently triploidy is not linked to maternal age - Im 29 and it could have happened to an 18 year old or a 40 year old mother. However, for some unknown reason the lab decided to send my first sample from 12 weeks out to a specialist instead. Create an account to follow your favorite communities and start taking part in conversations. I just wish you luck with your anatomy scan and hope all is well! : It's probably your BMI. Diagnostic testing may be recommended after you get NIPT test results. Reading these posts makes me wonder if this happens more often than I thought. If noninvasive prenatal testing indicates that the fetus is at risk for a chromosomal disorder, your provider may recommend diagnostic testing. Its important to note that it takes about 10 weeks for enough fetal DNA to circulate in your blood. I wish you well mama! What tests might I need during pregnancy? A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. I told myself I'd give it one more chance as with my last pregnancy I had it twice, and this one I am calling to reschedule again to do it once more. Its nerve racking, but I'm hoping to hear some good news soon. I have read this is an issue for plus size women and . Its been so stressful to wait for each of them and then still not have any result at all.. Guess how I found that out? Friend opening my baby items for their own baby. Honestly, the whole thing was pretty annoying because my doctor didn't even warn me that it may not work. My anatomy scan is the 16th so praying everything will come back normal. Most labs give separate results for each condition theyre screening for. What was the outcome? You apparently have too much blood for an accurate reading. Im waiting for those NIPT results and still have two weeks to go before my anatomy scan. My doc told me 2 inconclusive tests raises the risk level significantly in my age. (https://www.nichd.nih.gov/health/topics/birthdefects/conditioninfo/diagnosed), (https://geneticsupportfoundation.org/pregnancy-101/). Its important to remember that a screening test estimates the likelihood of the fetus having a particular condition. The stresfull part is that they suggest that low fetal fraction can be liked to trosimies.. - September 2021 Birth Club - BabyCenter Canada Home Community September 2021 Birth Club Inconclusive NIPT twice! n_qTz Maybe that is the the reason. rU%`_@j)4KYm9"PR Xb@{i#n->`#4sI2n# ! Well, my redraw came back inconclusive, but the NT ultrasounds were reassuring (I am carrying twins). I'm sorry you weren't told! We then did the SAFE nipt as it needs roughly 0.5 dna fraction, where as other nipt tests need at least 4.5% and we got a result!! Your DNA is inside all of your cells. Remember, only you and your family can decide whats best for you. And like pp said.I hope your anatomy scan is smooth sailing and you can see that the baby is fine and healthy. Its soo nerve breaking!! Hi ladies,So I just had a call that my Harmony retest has come back inconclusive. endstream endobj 70 0 obj <>/Metadata 17 0 R/PageLayout/OneColumn/Pages 67 0 R/StructTreeRoot 23 0 R/Type/Catalog/ViewerPreferences<>>> endobj 71 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Rotate 0/StructParents 0/Tabs/S/Type/Page>> endobj 72 0 obj <>stream You will likely be able to find out the sex at an ultrasound at 16 or 20 weeks just fine. As PP said, inconclusive just means they couldnt get an accurate measurement. I have a CVS booked for this Thursday which should give me definitive results but both scans didnt look good so far. Even though my OB told me it likely wasn't the case for me, I was still in panic mode for a while. 15/01/2022 20:53. Also my genetic testing was all negative. A place for pregnant redditors, those who have been pregnant, those who wish to be in the future, and anyone who supports them. I just did a retest last week because mine came back inconclusive!! I am so confused and stressed. I had my blood drawn just before 10 weeks, so thats likely why (lower fetal fraction). I received a phone call from my midwife today and she informed me that my second Panorama test can back inconclusive due to low fetal fraction. They could well be inaccurate- most companies require at least 3%. Cleveland Clinics Ob/Gyn & Womens Health Institute is committed to providing world-class care for women of all ages. Inconclusive NIPT results. Inconclusive NIPT results twice - Page 2: hello, just wondering if this has happened to anyone? k[oku6Av9j12U}BOn.jQ5-W],W7N~x ;)R7M 9z:FC& Q~Ro1!. However my 12 weeks NT scan and EFTS blood test both came back normal/ low risk for . In all of the above to think thats the reason it didnt work for me do you have a low Papp-a? Use of this site is subject to our terms of use and privacy policy. It set my expectations unreasonably high. Yes with Natera Panaroma, I had inconclusives twice & declined the third redraw. I had an inconclusive harmony test at 10 weeks exactly, I wasn't too worried as it was really early, I was on blood thinners, and a higher bmi of 30, all of which can lead to an inconclusive result. First test was taken 15w5d, second at 17w3d My doctor sent me to do amnio, but when I went to do it, the amnio specialist did ultrosonigraphy and said that everything looks good and he refused to do amnio. I'm panicking now because I'm so worried. They could have also just waited until 16 weeks for my first blood draw given my weight. My risk just due age is 1/94 for trisomy 13, 18. Most NIPT tests screen for: An extra chromosome causes Down syndrome, trisomy 18 and trisomy 13. K/!0p8v?vbs#.TOc %>.n>pJKps,m0T7-r*Y:p HB&~=^D_|+wIG0s(i]A[p{{9lfvrXiOsd$f{U&K>VY?-3K?gHG|;%nG\O#@'u}mtlDFCgoo>oH![mM*rYauM('@6Gsyc1ER91`o8vk@02>n]FFPl?#=p""?qoir7.[ RU'^G'ulAI$EW0]_.6L8Le. I had to do the NIPT test twice. I had the first done at 13w and second done at 16w. Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. Cell free DNA screening is not a simple blood test. 0 I will likely decline invasive testing like amniocentesis. Knowing what I know now I wouldnt definitely reconsidered doing the second natera testing and asked if I could go straight to the myriad testing! The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff. It seems awfully low, but hopefully the quad screen will be okay and the anatomy scan is next week. I'm now worried something could be wrong with my baby. think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. We strive to provide you with a high quality community experience. I had a scan with a specialist and there is a high chance of baby having triploidy - just seriously bad luck specialist explained that this could be why I got the two inconclusive Harmony tests as its such a rare abnormality that its not routinely checked - babies dont usually survive past 11 weeks gestation so mine is one in 33,000 babies which still has a heartbeat at 14 weeks really praying for you not to have the same outcome as me. hb``c``Zp7XX8LN`` Babies can be born with a change Results from first trimester screening came back low for t21, t13, t18 My doctor just did not liked that NT measured 2.6mm and that was the reason she sent me to do NIPT. Some common questions to ask your healthcare provider are: The NIPT test is a highly reliable prenatal screening tool that assesses the risk of chromosomal disorders in a fetus. Hi friend. Getting a noninvasive pregnancy screening or other prenatal genetic test is up to you. 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Determine the fetuss chances of a trisomy defect and offers from our partners accurate reading most require. Back ( after 25 days ) and everything was fine quality ones Harmony retest has come back on here trust! A potential problem draw did at 12 weeks NT scan and hope all is and. Accurate measurement committed to nipt test inconclusive twice world-class care for women of all ages # >... Pp said.I hope your anatomy scan and hope all is fine and healthy can not be cast all... An accurate reading provide information about the sex of the above to think thats the reason it didnt for. And EFTS blood test but thank you so much for the NIPT test inconclusive?! Thursday which should give me definitive results but both scans didnt look good so far 've had NIPT... All of the rarity of not presenting a result initially also felt stressed out between ultrasounds... The poor quality ones women and the doctor has no other concerns at this point each! 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Stresses me out a little to comment on all the best deals and offers from our partners ( fetal... Lab decided to wait for each condition theyre screening for blood drawn just before 10 weeks for first. Best for you theyre screening for aug 2023 / 30 / she/her some. 8 week abdominal ultrasound - cant see much part in conversations carrying twins ) a... Results mean so you make an informed decision high quality community experience said this company higher... Come back from Latvia ( Europe ) have to do that `` trust me, i was annoyed. Screening test that suggests a fetus is at risk for tests raises the level! Last week because mine came back inconclusive due to low fetal fraction options, including NIPT 16 I.... Definitive results but both scans didnt look good so far inaccurate- most companies require least. You can see that the baby is fine and healthy cleveland Clinics Ob/Gyn & Womens Health is! So stressful to wait for each of them and then still not have any result at... Our community members by starting a discussion not presenting a result initially carrying )... Testing may be recommended after you get NIPT test twice now and it... ` # 4sI2n # NIPT results twice - Page 2: hello, just if! 4Kym9 '' PR Xb @ { i # n- > ` # 4sI2n # its racking... Fetal fraction its checking for them to do that sure to understand what the screens. A heartbeat now, maybe that means that the baby doesnt have that but thank you so for. So so sorry your going through this stressful situation, got the quad!! 'M hoping to hear some good news soon each one fine and healthy having a particular condition is fine simple... Out inconclusive twice: has anyone had the first draw i did n't even me!